Glutamine-derived -ketoglutarate can fuel fatty acids synthesis through the reductive carboxylation mediated by isocitrate dehydrogenase (IDH)
As presented previously, we reiterate that NS is characterized by a persistent vicious cycle that emerges from the effects of OS, chronic pro-inflammatory status, hyperlipidemia, and metabolic imbalances
It appears to normalize the inflammatory response, allowing necessary acute inflammation while preventing the chronic state that impairs healing
In agreement with our results, a study by Shin et al
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Feng W, Weng Y, Shi W, Liang S, Liao X, Chu R