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Why is CUD such a big deal
The primary outcomes for the 23 trials are also given in Table 1
Subsequent trials (STEP 2 through STEP 8) confirmed these findings across diverse patient populations, highlighting the critical role of maintaining therapeutic doses (1.7 mg and 2.4 mg) to sustain weight loss and prevent weight regain
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Meanwhile, GLP 1 receptors in hypothalamic and brainstem nuclei reduce hunger, enhance satiety and shift food preferences away from calorie-dense options
Notably, these metabolic effects were uncoupled from changes in energy balance considerations, as food intake and weight gain remained unchanged
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