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Surgeons recommend weight loss before surgery to get below the BMI cutoff, and to further reduce post-surgical risks

doi: 10.3389/fphar.2017.00420 437 LiJZhaoXJiaoB

Combined treatment with GLP1R and GIPR agonists may result in improved metabolic and antidiabetic responses, with GIP indicating the potential of the agonist in CV health through its actions on lipid metabolism, insulin secretion, and cardioprotective properties 29

Pharmacological activation of thyroid hormone receptors elicits a functional conversion of white to brown fat

its a gateway to numerous devastating illnesses

Remember, these were originally prescribed as diabetes drugs