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Never shake vigorously as this can denature the peptide through mechanical stress

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Both strategies are leveraged in BsADC design, with biparatopic targeting primarily aimed at enhancing receptor clustering and internalization, while Bispecific targeting across different antigens can engage distinct biological pathways or exploit differential internalization rates [14]

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Time assessment: If over 30 days since reconstitution, potency is likely compromised regardless of appearance

Cell culture and STR analysis ARPE-19 human RPE cells were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA), and cultured in DMEM/F12 medium supplemented with 10% fetal bovine serum at 37 C in air containing 5% CO 2