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The meta-analysis showed that GLP-1 agonists were associated with 1.23 odds of pulmonary aspiration (P= 0.59 and 95% CI of 0.58 to 2.60, not statistically significant)
The GIP component appears to moderate the GI effects of the GLP-1 activation, which is the same reason Tirzepatide (dual GLP-1/GIP) is generally better tolerated than Semaglutide (GLP-1 only)
There is minimal overlap in their weight loss mechanisms, which suggests potential synergy rather than redundancy
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Novo faces tough competition from its main US rival and cheaper copycat obesity drugs
Does Semaglutide Cause Side Effects
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