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This is primarily mediated by the anti-apoptotic properties of sphingosine-1-phosphate (S1P) in HDL, which prevents the opening of mitochondrial permeability transition pores by activating the SAFE (Survivor Activating Factor Enhancement) and RISK (Reperfusion Injury Salvage Kinase) pathways

The methylcobalamin form in particular shows nerve-repairing properties, and has been shown to reduce homocysteine levels, treat peripheral neuropathy, ALS, multiple sclerosis, Alzheimer, Bells palsy, and other neurological disorders

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Potential treatment for abdominal aorta anastomosis: The peptide shows immediate benefits when applied as a bath immediately after anastomosis (7)