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You might notice suppressed hungerand changes in your eating habitswell before the scale starts to move

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Although the insulinotropic effect of GIP is diminished in patients with type 2 diabetes, studies have found that GIP receptor agonists can induce a degree of weight loss and, when used in combination with GLP-1, can produce synergistic effects, enhancing blood glucose reduction and weight loss

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GIPRs are abundantly expressed on -cells, and their activation induces a rise in cAMP and intracellular calcium levels, facilitating glucose-dependent insulin release from pancreatic -cells (118)