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The Endocrine Society's 2023 clinical practice guideline on pharmacologic management of obesity notes that GLP-1 RA gastrointestinal effects are "dose-dependent and generally diminish over weeks" 7
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For GLP-1R, the -carboxylate spacer formed two hydrogen bonds (with Y145 1.40b and D198 2.68b ), and the 16-carbon palmitic chain terminus dropped down along TM1 with the formation of massive hydrophobic interactions with I146 1.41b , T149 1.44b , V150 1.45b , A153 1.48b and L154 1.49b
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This means the same food intake and activity level that worked earlier may no longer produce the same results
That is one reason strength training, protein intake, and smart recovery matter so much
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