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The thymus starts to atrophy around age 15 and continues to decline until approximately 80-90% of its activity has decreased by age 35-45, which is when the chronic diseases of aging start becoming prevalent

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But they work in totally different ways: Sermorelin therapy: stimulates the pituitary gland to release growth hormone, which increases IGF-1 and supports bone, muscle, and metabolic function Estrogen therapy: binds to estrogen receptors rather than growth hormone receptors, impacting many of the same tissues, including bones, muscles, and fat As women balance the symptoms that arise during perimenopause and midlife, finding the right solution varies based on personal needs, body type, and other health factors

doi: 10.1210/jc.2002-021528 66 Diamanti-KandarakisEDunaifA

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