During viral infection, the antioxidant defense of the host is perturbed, resulting in oxidative stress 48
In addition, GPX4 has been shown to govern lipoxygenases activities in the AA metabolism ( 4 , 12-HETE, and 15-HETE) in the presence of GPX4 activator compound 102 ( Supplementary Figure S3B )
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Details of the methodology for high-performance liquid chromatography with electrochemical detection and metabolite quantitation have been previously described