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The name (Body Protection Compound) reflects its proposed role in tissue defense and repair

76,77 In summary, disc cells respond to altered loads and osmotic pressures, to DAMPs, MMPs and pro-inflammatory cytokines with the expression of catabolic enzymes, with anabolic healing attempts, and with inflammation resulting in failed healing attempts, damage accumulation and chronic inflammation leading eventually to DD

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Most gastrointestinal effects ease as the body adjusts over the first weeks

however, when the amount of E3 remained constant, the binding of E3 decreased with an increase in Pns11 (Fig