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Early animal studies suggest possible roles in wound healing and gut protection

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Life Sci 241:117051 Kremer J, Petrillo G, Hamilton R (1995) Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy

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