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The antidepressant response to LAC occurs after 3 days of administration and lasts for at least 14 days, whereas the action of standard antidepressant drugs (fluoxetine and clomipramine) requires 14 days of consecutive administration and disappears after drug withdrawal in the same rodent models [30, 34]
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The blood pressure-lowering effect appears to be driven primarily by weight loss (patients in the STEP trials lost 10-15% of body weight), though improvements in insulin sensitivity and vascular function may also contribute
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Patients with active suicidal ideation, recent psychiatric hospitalization, or unstable bipolar disorder should not start a GLP-1 agent through any telehealth platform without documented coordination with their treating psychiatrist
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