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Even if cysteine S -conjugate -lyase is responsible for the synthesis of the highly reactive and cytotoxic thiol version of cisplatin ( Figure 1 ), the activation of cisplatin into a nephrotoxin relies on the three previous steps of the classical mercapturic acid pathway involving GSTs (GSH conjugation), GT (production of CisPt-cys-glu) and dipeptidase (production of CisPt-cys

Zhao S, Yan Z, Du Y, Li Z, Tang C, Jing L, et al

References Giudice LC, Kao LC

A degraded peptide from improper storage might produce inconsistent appetite suppression and, potentially, inconsistent digestive side effects from dose to dose