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[9] Furthermore, in the phase 3 randomized, placebo-controlled 3-year SURMOUNT-1 trial for people with obesity and prediabetes, tirzepatide compared with placebo resulted in substantial and sustained weight reduction (1523% vs 2%), significant reduction in HbA1c (0.500.65% vs 0.14%), as well as a 94% reduction in risk of progression to T2D [10]