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Several potential mechanisms may contribute to fatigue during tirzepatide treatment, though the exact causes are not fully established

On average, patients may lose 5-10% of their body weight within this timeframe

Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma

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Underlying medical conditions such as hypothyroidism, Cushing's syndrome, or polycystic ovary syndrome may contribute to weight loss resistance