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Two reviewers reviewed their risk of bias individually for Random sequence generation (selection bias), Allocation concealment (selection bias), Blinding of participants and personnel (performance bias), Blinding of outcome assessment (detection bias), Incomplete outcome data (attrition bias), Selective reporting (reporting bias), and Other bias

An optogenetic stimulation of GLP-1Rs in habenular circuits was also shown to abolish nicotine reward and decrease nicotine intake in mice 109

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