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Zepbound (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults with obesity or overweight with weight-related comorbidities
After being produced by enteroglucagon-producing L cells in the lower gut in response to food intake, incretins travel to various receptors including the pancreas and cause glucose-dependent insulin release causing lowering of elevated blood glucose [1]
"The field is also exploring migraine, intracranial hypertension, inflammatory bowel disease, psoriasis, and rheumatoid arthritis, all out of my wheelhouse," he says
Side effects include mild stomach issues like nausea and diarrhea
Microdosing is custom-titrated at significantly lower levels based on response, tolerability, and metabolic goals, making it a more precise and often better-tolerated approach
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