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J Mol Biol (1978) 126:8715

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Additionally, the calculation of in-silico descriptors usually occurs for an isolated single molecule and does not account for the effects of neighboring molecules that would be present in a high-concentration solution

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In 3T3-L1 adipocyte cell models, 5-Amino-1MQ at 30 M concentration produced significant reductions in intracellular 1-MNA levels, confirming target engagement

Fat mass followed the same pattern