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( C ) The decreased GSH:GSSG increases LDH release, consistent with activation of oxidatively driven cell death ( n = 6)
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F329 and F332 on SRCR3 pack against P96 in -hairpin 2 of J chain through a van der Waals contact, plus a salt bridge between D72 and R328 (Fig
A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class
Proc Biochem 40:34743479
10.1097/HJH.0b013e3280127948 62 DayB
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