The table below is a general guide
Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity
Myong, S., Nguyen, A., & Challa, S
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That is generally desirable for tissue repair, but could theoretically influence tumor environments
Molecular mechanisms of thiamine utilization