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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardiaca y la presin sangunea, que pueden ser clnicamente significativas en algunos pacientes, habindose registrado casos de arritmias, cardiopatas isqumicas y accidentes vasculares graves con su consumo

Kim EL, Wstenberg R, Rbsam A, Schmitz-Salue C, Warnecke G, Bcker E-M, et al

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Severe obesity or type 2 diabetes requiring urgent intervention If a patients body mass index (BMI) is in the severe or morbid obesity range, or if they have uncontrolled type 2 diabetes with high blood sugar levels and/or A1C, waiting for thyroid stabilization could delay needed care

Key mechanisms include the relief of hypothalamic-pituitary-ovarian (HPO) axis inhibition through weight loss and improved insulin sensitivity, alongside improved endometrial receptivity driven by increased SHBG and decreased free androgens (83, 167, 168)