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Conclusion In conclusion, Semaglutide is a big step in treating weight and metabolic issues
Both the GLP-1 and GIP receptors are expressed on neurons in the arcuate nucleus and other parts of the hypothalamus, and their activation reduce food intake and body weight ( These findings have promoted an interest to discover the CV benefits of this pharmacological class extending beyond its glycemic effect
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[1] [4] Regarding fluid retention and oedema , these are not listed as common adverse reactions in the prescribing information for GLP-1 receptor agonists approved by the MHRA or EMA
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2014 Jun;27(3):317-29
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