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The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2

Exenatide weekly, Liraglutide &Dulaglutide have the most reduction effect on HbA1c ( Table 3 ) Table 3: GLP-1RAs summary of head-to-head clinical trials

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Cederbaum (2012) The Km of CYP2E1 for alcohol is 10 mM ,10-fold higher than the Km of ADH for ethanol but still within the range of alcohol concentrations seen in social drinking