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Kiyosue A, et al
PepZin GI Technical Monograph
Therapies that target hyperphagia are in development but understanding the value of these therapies to inform patient-focused drug development (PFDD) requires valid data on disease burden
GLP-1 medications are very effective at reducing calorie intake, so it may be especially challenging to eat less when you stop taking them
Similarly, the dual GLP-1R and GIP agonist tirzepatide promoted the intake of standard rodent chow at the expense of a high-fat diet in mice, suggesting a preferential shift toward less energy-dense foods (Geisler et al., 2023)
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