A 2025 study in Neuroscience Letters found that chronic administration of BDNF-stimulating compounds in rodents led to receptor desensitization within 16 weeks, requiring progressively higher doses to maintain effect
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doi: 10.1016/j.trsl.2012.05.001 165 AminiLChekiniRNateghiMRHaghaniHJamialahmadiTSathyapalanTet al
Additionally, preclinical animal models provide mechanistic insights but may not fully translate to human physiology, particularly in conditions such as osteoporosis, obesity-related bone changes, and joint infections