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It should be avoided or used only under clinician supervision in patients with kidney disease, older adults, or those at risk for electrolyte abnormalities , due to the risk of hypermagnesemia., Use sparingly: Stimulant laxatives (such as bisacodyl or senna) may be effective for intermittent rescue use , but they can cause cramping and are generally not needed for routine long-term management when osmotic agents are effective., Safety note: Regular stimulant laxative use that causes frequent loose stools may contribute to dehydration and electrolyte imbalance (including hypokalemia) and should therefore be intermittent unless clinician-directed . What about docusate (Colace)
The role of GSH as NO scavenger is also highlighted by Hu et al., 2012)
If you go month-to-month, the risk is manageable
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He has received grant support from Merck, Sharp & Dohme
Glutathione metabolism and [...]
