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And reduced abundance of Bifidobacterium bifidum similarly downregulates TPH1 and SERT expression, impairing 5-HT synthesis (Taverniti et al., 2021)
The SURPASS-CVOT (Cardiovascular Outcomes Trial) is an ongoing dedicated study designed to assess cardiovascular outcomes in patients with type 2 diabetes at increased cardiovascular risk
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Effects on substance use
The transcriptional hepatic effects of GLP-1GIPLani separated clearly from those of Lani and GLP-1GIP, which was also apparent by a robust shift in principal component analysis (PCA) (Extended Data Fig
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