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On the other hand, in cholestatic individuals in whom the NGS panels have not found pathogenic mutations, a comprehensive study like WES, performed over the full exome, can find potential gene candidates for a cholestasis association, as was the case with the most recently discovered PFIC, PFIC 13 [37, 90]

As research yields new insights and potential therapies, the market is expected to benefit from a pipeline of novel products that could reshape treatment paradigms

Aric Aghayan

These are quite safe and prescribed under professional supervision

If nausea persists beyond 3-4 weeks on a stable dose, consider reducing to the previous dose level and attempting re-escalation more gradually after 4-6 weeks

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