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Following an oral dose, NAC absorbs rapidly, reaching its peak plasma concentration within 1 to 2 hours, and has a relatively short terminal half-life of approximately 5.5 to 6.25 hours
Licensed professionals monitor dosage and patient response carefully
doi: 10.4014/jmb.2312.12051 132 LiTYuHSongYZhangRGeM
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Studies have demonstrated that daily oral administration of crystalline cyanocobalamin effectively normalizes serum cobalamin levels in deficient patients, although it is unsuitable for rapid supplementation in cases of severe deficiency due to the limited passive absorption
However, its impact on endosomal escape requires careful optimization, as PEG can hinder LNP fusion with endosomal membranes, a phenomenon often referred to as the PEG dilemma 174,175,176
