Semaglutide and the Future of Weight Management The introduction of semaglutide into the treatment landscape has sparked discussions about the broader implications for public health
Figure 7: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis) is linked to excess inflammatory proteins and fat deposits, which disrupt energy production and metabolism
42 The FIGHT trial, which enrolled patients hospitalised for acute decompensated HFrEF, showed no improvement with liraglutide on the primary composite endpoint of death, HF rehospitalisation or change in N-terminal pro B-type natriuretic peptide levels
N Engl J Med 2021;385:503-515
Genetic factors are also at play, and scientists are trying to understand more about this
Consistent with the electrophysiological recordings, behavioral studies showed that activation of GLP-1R in the ventral hippocampal CA1 regions reduces food intake and body weight, while targeted ventral CA1 GLP-1R knockdown increases food-motivated behaviors (Hsu et al., 2015, 2018)