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2 Overview of -blockers and their classification The mechanism of action of -blockers involves their competitive antagonism of adrenergic stimulation of beta-adrenoceptors through structural similarities to catecholamines, which stimulate beta-adrenoceptors (1, 2 and 3) as well as alpha-adrenoceptors (1 and 2)

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Up to 3,000 people will take part in the first-of-its-kind 'real world' trial, set up under 279m plans by US pharmaceutical giant Eli Lilly and the government to address public health challenges like obesity

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