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[3] [4] This metabolic involvement has led some to speculate about a connection between B12 and energy or fat metabolism a claim that warrants careful scrutiny

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The most common include: Nausea or "queasiness" Changes in bowel habits (constipation or diarrhea) Acid reflux/heartburn Mild fatigue Note: Some patients find Tirzepatide slightly easier to tolerate because the GIP hormone may help offset some of the nausea caused by GLP-1

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Human studies have examined weight loss results, HbA1c changes, liver-fat reduction, blood pressure, lipids, and other metabolic markers