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Another drug, activated protein C, reduces BBB breakdown and leakage in stroke model rodents and has anti-inflammatory effects, neuroprotective effects, and blocks hemorrhage after brain ischemia [126, 127]
10.1016/j.biomaterials.2016.05.040 51 HaiderS.LipskaK
Side effects are generally minimal at this level
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At higher doses (1.52mg), the incidence of gastrointestinal symptoms increases, and the theoretical risk of phosphate dysregulation becomes more relevant
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