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This is one of the most common questions providers hear from patients on GLP-1 medications, and there is rarely a single, simple answer

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Short-term use of loperamide may be appropriate for acute episodes, but this should only be done under medical supervision and avoided if you have blood in your stool, fever, or suspected infection

Additional risk factors include birth defects [293], a family history of GCT in a first-degree relative [294] and personal history of GCT [295]

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