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The hyperglycaemic effect of glucagon may depend both on glycogenolysis in a dose-dependent manner, mediated through cAMP and on transcription-dependent changes in rate-limiting gluconeogenic enzymes, such as PEPCK

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The enzyme preferentially cleaves dipeptides such as Arg-Arg, Ala-Arg, Asp-Arg, and Tyr-Gly [12]

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Glucagon-like peptide-1 (GLP-1) is a hormone produced by the stomach in response to food, which plays an important role in regulating appetite and blood sugar levels