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For gallbladder or biliary disease, the composite of gallbladder or biliary disease was significantly associated with tirzepatide compared with placebo or basal insulin (RR 1.97, [95% CI] 1.14 to 3.42

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EWDR was reported in people with type 1 diabetes undergoing intensive glucose lowering as part of the DCCT trial [5] and has also been described in people with type 2 diabetes in small casecontrol studies [6]

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Essential role of nonessential amino acid glutamine in atherosclerotic cardiovascular disease