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The area under the curve (AUC) for each line equals the total amount of drug present in the systemic circulation for each administration The application of the equation: Now we just need to apply the equation: Say for example we administered 500mg of drug in both situations

Add 2.5 mL of bacteriostatic water to the 10 mg vial

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The dose of berberine commonly used in randomized controlled trials is 300-500mg 3x per day

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It naturally prevents tolerance by limiting exposure and may be appropriate for those with generally good sleep who experience periodic difficulties