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Observational studies have shown that GIP receptor mutations lead to decreased receptor signaling, which results in lower BMD and increased risk of fractures [50]
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The researchers recruited 120 individuals with excess weight and obesity (74 women and 46 men) for the analysis
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Likewise, the results of large clinical trials employing cardiovascular surrogate markers as their secondary outcomes also imply the potential beneficial effects of GLP-1 RAs in the cardiovascular system in human subjects
E.ChapmanB.KuchelP
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