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Semaglutide is used to control blood sugar levels in people with type 2 diabetes to help with weight loss

In a 48-week phase II clinical trial conducted on patients with type 2 diabetes and obesity, treatment with a dose of 10 mg/kg of bimagrumab resulted in a significant reduction in fat mass by 20.5% (compared to 0.5% in the placebo group), while lean body mass increased by 3.6% (as opposed to a decrease of 0.8% in the placebo group), leading to an overall body weight reduction of -6.5%, which was substantially better than the -0.8% observed in the placebo group

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This is because it is in keeping with the clinical trial, and there is no evidence of effectiveness if semaglutide is used as a single stand-alone treatment. Semaglutide is the active component in Ozempic and Wegovy, while the active component in Mounjaro and Zepbound is another GLP-1 called tirzepatide

The MGF E-domain activates quiescent satellite cells, stimulating their entry into the cell cycle and proliferation as myoblasts

Strain-specific evidence is evolving