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Lancet 12

These companies are watching price erosion following the initial wave before committing

Seek emergency medical attention (call 999 or attend A&E) if you experience: Severe, unrelenting abdominal pain particularly if accompanied by fever or vomiting Signs of gastrointestinal bleeding vomiting blood, passing black stools, or feeling faint Symptoms of severe dehydration inability to keep fluids down, reduced consciousness, or minimal urine output Suspected allergic reaction facial swelling, difficulty breathing, or widespread rash Seek urgent same-day assessment if you develop: New visual changes particularly if you have diabetes or pre-existing retinopathy (contact your GP, diabetes team or eye casualty) Persistent vomiting lasting more than 24 hours Severe diarrhoea more than six episodes daily or lasting beyond 48 hours Unremitting nausea preventing normal eating or drinking New or worsening abdominal pain that differs from initial side effects Contact your GP or prescribing clinician within 2448 hours if you develop: Symptoms of gallbladder disease right upper quadrant pain, especially after eating fatty foods Unexplained fever with abdominal symptoms Difficulty taking other essential medications due to gastrointestinal symptoms Persistent dyspepsia despite simple measures Routine follow-up is appropriate for: Mild, manageable nausea or altered bowel habits Questions about dose titration or administration technique Discussion of symptom management strategies Scheduled monitoring appointments NICE guidance (TA875) on obesity management emphasises the importance of regular clinical review for patients on pharmacological weight management treatments

This comprehensive assessment ensures that Zepbound is the right choice for your specific situation, whether youre managing obesity, type 2 diabetes, or other metabolic concerns

Only branded finished products like Wegovy, Ozempic, Zepbound, and Mounjaro hold FDA approval

Mir Ali, bariatric surgeon Experts agree the FDAs new indication for semaglutide is needed