In addition, obesity-associated adipose tissue inflammation further exacerbates CNS inflammation, creating a vicious cycle of metabolisminflammationneurodegeneration (Chen et al., 2024
Therefore, exercise interventions may regulate iron metabolism-related protein expression, influence systemic iron homeostasis, and consequently delay the pathological progression of NDDs
The brand name Zepbound is FDA-approved for chronic weight management
Allocation, randomization and blinding Mice were randomly assigned to treatment groups (vehicle/semaglutide
Participants received either mazdutide 6mg or semaglutide 1mg for 32 weeks
The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4