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DOI: Published: Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-642-24715-6 Online ISBN: 978-3-642-24716-3 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

If the previous beliefs and protocols cannot be proven safe or effective with the new information available, then we MUST re-evaluate and reconfigure our beliefs and protocols to maximize safety and efficacy