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Amy Rothberg, a metabolism, nutrition, and diabetes expert at the University of Michigan, told Insider

( D ) Protein expression of tumor necrosis factor (TNF)-, * vs

Proc Natl Acad Sci USA 115(48):1231312318

While individual responses vary, there is a physiological basis for this: different sites have different rates of absorption, and slower absorption may reduce the intensity of GI side effects