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However, there are critical distinctions: Rodents have a much higher density of GLP-1 receptors on thyroid C-cells than humans Human thyroid C-cells show minimal GLP-1 receptor expression No causal link between semaglutide and thyroid cancer has been established in human clinical trials involving over 10,000 participants (Bjerre Knudsen et al., 2010, Endocrinology ) A large pharmacovigilance study published in Diabetes Care found no increased risk of thyroid cancer among GLP-1 receptor agonist users compared to other diabetes medications (Bezin et al., 2023, Diabetes Care ) Despite this reassurance, the following patients should avoid semaglutide: Those with a personal history of medullary thyroid carcinoma (MTC) Those with a family history of MTC Patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with common hypothyroidism (typically Hashimotos thyroiditis or post-surgical hypothyroidism), these contraindications do not apply