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UV exposure triggers new pigment and darkens existing spots

Contact your GP or diabetes specialist nurse within 2448 hours if you experience: Persistent dizziness that does not improve with hydration and dietary adjustments Recurrent episodes of dizziness, particularly if they interfere with daily activities Dizziness accompanied by frequent hypoglycaemia (blood glucose below 4.0 mmol/L on multiple occasions) Unexpected, very rapid, or concerning weight loss , or if you're unable to maintain adequate food intake Inability to maintain adequate fluid intake due to gastrointestinal side effects Dizziness associated with palpitations or irregular heartbeat Seek immediate medical attention (call 999 or attend A&E) if you experience: Severe dizziness with loss of consciousness or near-fainting episodes Chest pain, shortness of breath, or severe palpitations accompanying dizziness Severe, persistent vomiting or diarrhoea leading to signs of dehydration (dark urine, dry mouth, confusion) Neurological symptoms such as slurred speech, visual disturbances, weakness, or severe headachethese may indicate conditions unrelated to your GLP-1 medication that require urgent assessment Severe abdominal pain , particularly if radiating to the back, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 agonists) if you suspect pancreatitis, withhold your GLP-1 medication pending medical assessment Right upper abdominal pain with fever or yellowing of the skin/eyes , which could indicate gallbladder disease Your healthcare provider will conduct a thorough assessment , which may include checking your blood pressure (both lying and standing), reviewing your blood glucose records, assessing your hydration status, and potentially ordering blood tests to evaluate kidney function and electrolyte balance

For gastrointestinal indications, systemic or oral administration is appropriate because the entire gut is the target

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Results showed that the combination of topical and oral glutathione significantly reduced melanin index and increased skin brightness compared to placebo and monotherapy groups

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