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Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis
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Little leukotriene synthesis occurs in resting cells, but this is stimulated by cellular events that raise the level of calcium ions, while the enzyme is regulated by phosphorylation at three serine residues by kinases
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