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Cesar LB et al

Cells occupying the same microenvironment may simply be exposed to a shared upstream insult, such as hypoxic, ischemic, toxic, or inflammatory stress, leading to simultaneous but independent ferroptotic responses

An estimated 51.3% of MASLD patients are obese, and the percentage rises to 81.8% in MASH, 22 with approximately 1020% categorized as lean MASLD