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Rybelsus (oral semaglutide 3 mg, 7 mg, and 14 mg) is FDA-approved for type 2 diabetes management, not for weight loss or obesity

However, these latter effects are currently only observed in animal studies

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Considering this evidence, we hypothesised that activation of the GLP-1 pathway in the OB activates GABAergic neurons in the LH, which inhibit PVN neurons, reducing their stimulation of preganglionic sympathetic neurons

GLP-1 plays a key role in regulating blood sugar levels by stimulating insulin release, reducing appetite, and slowing gastric emptying