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doi: 10.1016/j.mam.2012.11.003 136 SongFFYiYDLiCHuYJWangJHSmithDEet al

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[57] AD is associated with an accumulation of DNA damage (double-strand breaks) in vulnerable neuronal and glial cell populations from early stages onward, [58] and DNA double-strand breaks are increased in the hippocampus of AD brains compared to non-AD control brains